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As input substitution across other inputs (training, building and office expenses, monitoring and evaluation etc) is limited, it was valid to exclude all prices except for one, the cost of rent (rent) representing regional variations in prices of locally purchased goods[ 35, 37, 38].
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Neither ethical nor legal considerations provide valid reasons to exclude 13 15 year olds from trials of contraceptive agents, subject to appropriate ethical approval.
Quite certainly, there are no valid reasons to exclude beneficiaries in humanitarian aid programmes from systematically evaluated health care any longer.
Although the reason for the apparent discrepancy is not obvious now, possible reasons may emerge in the future and it is important for advancement of science to record "unexpected" findings when there is no valid reason to exclude them.
Box 2 Suggested guidance for research ethics committees reviewing studies of contraceptive agents in children <16 years of age Neither ethical nor legal considerations provide valid reasons to exclude 13 15 year olds from trials of contraceptive agents, subject to appropriate ethical approval.
37 38 Generation of valid data is essential to exclude days of accelerometry from the analysis when the participants do not wear the device for a period of time deemed sufficient to interpret levels of activity.
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