Based on the results of validity, responsiveness and reliability testing, the SAQ has been judged to be a valid, responsive and reliable instrument [ 24].
The CMIs we used have all undergone various degrees of validation (responsiveness, criterion validation), with the CBPI and the LOAD being the most evaluated and considered the most valid [ 26- 29].
We hypothesised that ChIMES would be reliable (test retest, inter-rater and internal consistency) and valid (convergent validity and responsiveness).
Some of the experiments were performed on small sample numbers, but since results were consistent throughout, we believe the results to be valid in determining responsiveness of immune cells of osteosarcoma patients to IFN-α.
It has been shown to be a reliable, valid and responsive multidimensional outcome measure in patients with osteoarthritis of the hip or knee [ 64] and has been found to demonstrate superior responsiveness to the Lequesne Algofunctional Index [ 65].
These last results are consistent with a previous report conducted in patients undergoing cardiac surgery and showing that the bioreactance-based NICOM system was clinically valid to predict fluid responsiveness from changes in cardiac output during PLR [10].
The EQ-5D appears to be a reasonably valid instrument with moderate responsiveness in patients with anxiety disorders.
It is also widely acknowledged that where GRCs are not available, statistical approaches to evaluating responsiveness are valid [ 21, 22, 27, 28, 37].
When univariate logistic regression analysis was used (Table 2), only a low frequency of plasmablasts was a valid predictor for EULAR responsiveness (odds ratio of 2.22; P ≤ 0.04).
These last results are consistent with a previous report conducted in patients undergoing cardiac surgery and showing that the bioreactance-based NICOM system was clinically valid to predict fluid responsiveness from changes in cardiac output during PLR [ 10].
