Of note a synergistic or additive activity with valid treatment regimens of targeted cancers and now targeted small molecules.
However, while this is valid for regimens that are low cost, or with new single agents when compared to no chemotherapy, it may not be the case when these new agents are combined with cisplatin as patients may still need hospitalisation, and overall the treatments may become very much more expensive.
Thus, early initiation of everolimus at a targeted blood trough level of 3 8 ng/mL in combination with reduced exposure tacrolimus provides a positive outcome in terms of benefit to risk ratio, representing a valid alternative to existing regimens in liver transplantation.
As both agents are clinically approved and readily available, this regimen constitutes a valid alternative for patients with relapsed or refractory CLL.
More importantly, in 10%% of cases, the recommendation to modify the drug regimen was not valid, and could even be considered as deleterious, which is not acceptable.
Network-based intervention has been a trend of curing systemic diseases, but it relies on regimen optimization and valid multi-target actions of the drugs.
(IV) Switching to a different oxaliplatin/Fp regimen is a valid option in the event of controlled disease but poor tolerance or compliance and should be considered before abandoning this regimen and moving to a second-line regimen.
We believe that a 10-day sequential regimen could be a valid alternative therapy in initial treatment for the eradication of H. pylori in duodenal ulcer scar patients.
The data suggest however that the application of drugs that circumvent ABC transporters could therefore represent a valid addition to current MB chemotherapy regimens, particularly in high risk MB.
The control arm (5-FU/FA) was valid from a UK perspective as this regimen is most commonly used in the UK (Seymour et al, 1997).
