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Finding valid instrumental variables is not trivial.
To investigate whether physicians' prescribing preferences were valid instrumental variables for the antidepressant prescriptions they issued to their patients.
To overcome this endogeneity problem, either a valid instrumental variable or a convincing quasi-experimental design is needed.
To investigate whether physician's prescribing preference is a valid instrumental variable (IV) for patients' actual prescription of selective cyclooxygenase-2 (COX-2) inhibitors in the German Pharmacoepidemiological Research Database (GePaRD).
Our discussion of the role of the distribution of physical attractiveness in the population highlights the challenge of implementing a valid instrumental variable strategy for the relative spouses' BMI in the household.
For example, variants in the CRP gene are likely to be valid instrumental variables for CRP.
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The instrumental variables approach requires a valid instrument for required schooling in addition to the usual instrument for schooling.
We tried to correct this bias with instrumental variables, but we did not find valid instruments in our data.
Using an instrumental variable approach to address this problem we find a set of valid instruments that can be used in future studies of air travel demand.
Three assumptions must be valid to successfully use instrumental variables: first, the instrumental variable must be relevant and associated with exposure; second, that the variable must affect the outcome only through the likelihood of exposure; and (3) the instrument is unrelated to confounding variables.
Our instrumental variable is valid under the assumption that patients' decision to leave is not driven by the number of people at the ED, but by the wait time faced (which increases when the ED is crowded).
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com