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Furthermore, a lab-scale proof-of-concept experimental set-up has been constructed to valid effectiveness of the design.
Considering the substantial morbidity, mortality and costs associated with pneumococcal disease as well as the limitations of Markov models to simulate the dynamics of transmissible disease, there is a need for more accurate models as soon as valid effectiveness data of PCV13 is published to confirm the cost-effectiveness of this vaccine.
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Comprehensive simulations confirm the theoretical analysis, and valid the effectiveness of our proposed scheme.
However, longer term follow-up is required to valid the effectiveness of RAMP-DM over a longer time-span.
There is a critical need for valid comparative effectiveness studies of cancer screening tests, but this is often hampered by uncertainties about the exact reason for testing.
There are no published randomized controlled studies involving prostate cancer patients with sufficient patient numbers to enable a statistically valid comparative effectiveness analysis between SF and MF regimens in prostate cancer patients.
Given the impending ageing population and limited health care resources, reliable and valid cost-effectiveness analyses of interventions targeted at people with dementia is an important task for both researchers and policy makers [5].
Additionally, correct cost estimates are needed as inputs for valid cost-effectiveness studies.
All in all, having a framework for CEA that incorporates time and quantifies short-run deviations could help prevent unpleasant surprises, and provide an implementation decision process with more valid cost-effectiveness data.
It is anticipated that the findings from this study could serve as a basis for determining a valid cost-effectiveness threshold value for Malaysia, which could, in turn, assist health authorities in making informed funding and reimbursement decisions and in formulating health policies.
Although these estimates are based on valid studies, vaccine effectiveness estimates are season- and strain-specific (due to factors such as variations in the vaccine/virus match and the time between vaccination and exposure), thus affecting the generalizability of the figures on averted cases and costs.
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