(1) Outcome parameter diabetes: Highest evidence was expected from blood glucose measurements with internationally valid cut off-levels as defined by the American Diabetes Association or WHO (O = 1) [ 32].
However, estimation of externally valid cut-off values for serum 25(OH D in smokers is hindered.
Establishing multiple valid cut-off points using a psychosocial variable to establish risk of poor outcome is difficult.
Having a reliable marker like UC and a valid cut-off point that is able to discriminate regular or occasional smokers from non-smokers are critical issues.
Using ROC curve analysis, we defined a valid cut-off value for the number of mitotic figures as ≥ 2 mitoses per 10 HPF in APA cases.
Our data, comparing the scores of students reporting psychological stress to those reporting no stress, confirms that 1.0 is a valid cut-off point separating those who are in distress from those who are relatively unaffected by psychological problems.
To determine a valid cut-off point for a definition of "first" or "new" prescription in indicators for the assessment of the quality of antibiotic drug treatment on the basis of pharmaceutical data.
Although tumour growth in responsive patients may be closely linked to an increase in EGFR/CEP7 ratio, the literature in other tumour entities, especially in metastatic colorectal cancer demonstrates the experimental difficulties in finding a valid cut-off [ 19].
Note that the MBI originally was not developed as an individual diagnostic tool, and that only for the Netherlands clinically valid cut-off points seem to be available [ 7, 35].
The criterion of three chronic conditions minimum was considered to be a more valid cut-off score for multimorbidity in elderly patients treated in the ambulatory care setting instead of the usual two chronic conditions criterion, frequently leading to very high rates of multimorbidity in the age group over 65 years [ 20], as in our data set as well.
Using a cut-off score on the HADS-depression scale of 8, a valid cut-off in screening for depression (18), women taking glucocorticoid therapy were twice as likely to report symptoms of depression (OR 2.35 (1.35–4.5), P=0.005) compared with women not taking glucocorticoid therapy.
