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It should be noted that no statistically valid changes in viability of leukemic cells subjected to irradiation with visible light or fullerene C60 separately were detected (data not shown).
Although methods for valid changes to sample size parameters mid-trial are emerging, 37 no such method was mentioned in any study in our sample.
The use of outcome measures which are valid, reliable and sensitive to change is vital when considering the effects of treatment in order to detect valid changes which are greater than measurement error [ 61].
Only logically valid changes in smoking status were allowed; subjects were censored when they reported an invalid transition (such as current smoker on one occasion and lifetime non-smoker on a later occasion).
Following elucidation of biologically enriched themes, the microarray data was re-mined and analyzed with focus on identifying and interpreting all statistically valid changes gene expression associated with the highlighted pathways.
In instances where fatality and crash data are available, roadside survey data may still be useful to confirm that changes in crash data reflect valid changes in drinking-and-driving behavior rather than other changes not related to alcohol consumption (e.g., roadway improvements) (Roeper and Voas 1998).
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Although the Western Ontario and McMaster University Osteoarthritis Index (WOMAC) is considered the leading outcome measure for patients with osteoarthritis of the lower extremity, recent work has challenged its factorial validity and the physical function subscale's ability to detect valid change when pain and function display different profiles of change.
We also had to demonstrate the valid application of the bMCU test both as a pre- and a posttest to reflect learning progress (valid change measure) and examine the test's reliability by interpreting item information curves.
We lack a test with confirmed suitability for inter-individual comparisons independent of the test taker's individual characteristics (fair measurement), which not only enables one-time measurement but also can reflect learning progress (valid change measure).
We investigated whether our new test can provide fair measurement and constitutes a valid change measure by testing the fit of one uniform Rasch model both on data from different groups of test takers (e.g., female and male students) and on pre- and posttest data (see, e.g., Bond and Fox, 2007; Hambleton and Jones, 1993; Lord, 1980).
The construction and evaluation of the instrument enabled us to create a fair, user-friendly, short, and exact test of conceptual knowledge (fair measurement and efficiency) that is adapted to the content taught to secondary school students (content validity at secondary school level) and that can be validly applied both as a pre- and posttest to reflect learning progress (valid change measure).
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CEO of Professional Science Editing for Scientists @ prosciediting.com