ELISPOT responses to the CS antigen were significantly higher than pre-vaccination values after the second and third immunization in RTS,S/AS01E and RTS,S/AS02D vaccinated children.
One month after 2-dose catch-up in the second year of life, for each vaccine pneumococcal serotype, antibody GMCs increased by 17.0- to 512.2-fold 512.2-foldaccination values.
For PPV, antibody levels to several serotypes decline to pre-vaccination values within 5 10 years corresponding to a decline of protection.
In a clinical trial, adolescents who had received a booster dose of reduced dose diphtheria tetanus-5-component acellular pertussis vaccine (Adiphtheria tetanus-5-componentmaintainediphtheria tetanus-5-componenttions to acellularens compertussish pre-vaccinetion vAdacel®
Wilcoxon matched-pair signed-rank test for non-parametric data was used for analysis of pre- versus post-vaccination values for each individual.
In both study groups, the frequency of CS-specific IL-2+ CD4+ T cells was significantly higher at one month post dose 2 and one month post dose 3 compared to pre-vaccination values.
One year after last vaccination (month 14), the frequency of CS-specific circulating memory B cells had decreased in both groups but was still significantly higher than pre-vaccination values.
Fold increases relative to pre-vaccination values (ratios of post-vaccination value to pre-vaccination value) were determined.
Fold increases relative to pre-vaccination values (post-vaccination value to pre-vaccination value ratios) were determined.
If a pre-vaccination value was 0, more than 30 post-vaccination values were considered augmented responses.
