10 The primary analysis in a ring vaccination trial estimates vaccine efficacy against disease.
It is possible that in a ring vaccination trial, an efficacious vaccine may not be shown to be so, either because the ring vaccination delivery strategy or the ring vaccination trial design is unsuitable for the vaccine.
To estimate overall vaccine effectiveness, a ring vaccination trial with delayed vaccination can compare the incidence of disease between rings randomised to immediate or delayed vaccination by including events among unvaccinated individuals in all rings.
As noted, a ring vaccination trial tests both the vaccine and the vaccination strategy.
3 6 A ring vaccination trial therefore tests both the vaccine and the approach.
PneuMum is a randomised controlled maternal vaccination trial, using 23-valent Pneumococcal Polysaccharide Vaccine (23vPPV) during the third trimester or at delivery compared to vaccination at 7 months post delivery.
This repertoire was compared to that induced by a subsequent immunization with the monovalent inactivated vaccine against 09 MIV, and a third vaccination trial with the 2014/2015 TIV, which includes the 2009 pdmH1N1 HA antigen.
This study confirms the finding of Minke et al. [ 4] that there were significant differences in immunogenicity between the vaccines A and B in an experimental vaccination trial in laboratory dogs.
He and his colleagues recently completed the first conservation vaccination trial for chimpanzees - testing an experimental Ebola vaccine on a group of chimps at a primate centre in the US - the last developed country where biomedical testing on captive apes is permitted by law.
In March 2015, a phase 3 ring vaccination trial of a recombinant vesicular stomatitis virus Zaire Ebola virus vaccine began in Guinea (2 ).
In this paper, we describe the design considerations behind the protocol for a ring vaccination trial, a novel cluster randomised controlled trial to evaluate vaccines against EVD in Guinea, West Africa.
