Sentence examples for vaccination therapy from inspiring English sources

Although the lack of defined antigens in RCC has hindered more specific vaccine development, research regarding vaccination therapy has been of special interest for the treatment of RCC for more than 30 years.

12 A variety of immunotherapies targeting EGFRvIII are currently under investigation including monoclonal antibodies, dendritic cell vaccination therapy, genetically modified T cells, and peptide vaccines.

In this chapter, we have summarized a number of clinical trials performed in various cancers with focus on the clinical outcome of vaccination therapy.

Results of a number of larger trials in the past few years have indicated that vaccination therapy can also have a detrimental effect and be associated with worse outcome.

These results indicate that a vaccination therapy using DCs coinfected with the two tumor-associated antigen genes is an effective strategy for immunotherapy in the activation of DCs, CD4+ T cells, and CD8+ T cells, and may be useful in the clinical application of cancer vaccine therapy.

These results indicate that a vaccination therapy using DC co-transduced with the TAA gene and IL-18 genes is effective strategy for immunotherapy in terms of the activation of DCs, CD4+ T, cells and CD8+ T cells, and may be useful in the clinical application of a cancer vaccine therapy.

MHC class I-restricted peptide-based vaccination therapies have been conducted to treat cancer patients, because CD8+ CTL can efficiently induce apoptosis of tumor cells in an MHC class I-restricted epitope-specific manner.

Direct targeting of antigens to DC surface receptors in vivo might replace laborious and expensive ex vivo culturing, and facilitate large-scale application of DC-based vaccinatherapiesapies.

So far, DTH has been the only suitable parameter for the evaluation of anti-tumour immunity and the best early predictor of clinical efficacy of vaccination therapies (McCune et al, 1990; Harris et al, 2000; Baars et al, 2000; Clay et al, 2001).

Virus-like particles (VLPs) are of interest in vaccination, gene therapy and drug delivery, but their potential has yet to be fully realized.

Accordingly, 70% of recombinant protein pharmaceuticals and most proteins used for vaccination, human therapy or diagnostics are currently produced in mammalian cells [5].