The two included studies in the vaccination meta-analysis were both conducted at research facilities.
Previous BCG vaccination; a meta analysis reported increased likelihood of a positive TST in BCG-vaccinated persons within the first 15 years after vaccination [ 27].
Search terms were "influenza," "vaccine* or vaccination," and "meta-analysis or pooled analysis or systematic review" in all fields.
As regards harms, the findings were similar to those on H5N1 vaccination: both meta-analyses found a higher (and high) frequency of mild or moderate adverse events by oil-in-water adjuvants, although they concluded that such a lower tolerability could be acceptable in a pandemic, and a low rate of serious adverse events (three, all solved in 10 d, out of 22,826 vaccinated subjects).
The reduction in HPV infections for varying programs of girls-only and girls and boys vaccination was estimated by meta-regressions on outputs from Brisson et al's (2011) dynamic Canadian model [ 13], which allowed for changing likelihood of acquiring HPV over time and herd immunity effects.
In the second meta-analysis, cardiovascular diseases accounted for 17.2 20.0%% of all influenza-related hospitalizations [ 29], and in the third meta-analysis, influenza vaccination reduced the risk of severe complications by half (risk ratio 0.57, 95%% CI 0.39 – 0.82) [ 30].
In our meta-analysis, Gardasil vaccination of HPV-naïve women was associated with a 32% reduction in proportion of women with ASCUS+, a 22% reduction in cervical biopsies (based on one study only), and reductions of 49%and47%7% in CIN2+ and CIN3+, respectively.
Meta-analyses indicate that vaccination with whole-tumor antigens induced greater clinical responses than vaccination with defined tumor antigens for GAA expression heterogeneity [ 62, 63].
Pre-pandemic "avian" H5N1 and pandemic 2009 (H1N1) vaccines can achieve satisfactory immunogenicity, but no meta-analysis has addressed H1N1 vaccination impact on clinical outcomes.
Arnoldussen, D. L., Linehan, M. & Sheikh, A. BCG vaccination and allergy: a systematic review and meta-analysis.
To ensure reliable comparisons between strategies we used the same set of 50 000 meta-scenarios to model each vaccination strategy.
