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The idea of a ring vaccination design, never before used in a formal vaccine study, "was absolutely very creative," says Osterholm, and it allowed the team to follow the epidemic wherever it went.
They collaborated closely with the government and local authorities in Guinea and chose a "ring vaccination" design for the trial, which was unusual but had been successful in helping stamp out smallpox decades ago.
These findings are relevant to vaccination design for elderly populations.
The study, organized by the World Health Organization in a consortium with many other agencies, used an unprecedented ring vaccination design, in which the contacts of new Ebola cases as well as the contacts of contacts were vaccinated.
These sites could be targets for vaccination design strategies based on epitopes and/or as markers in the implementation of diagnostic techniques.
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Vaccination designed to expand CTL, specific for tumour-associated antigens, may be a means of improving outcome.
A combined strategy of drug treatment for the expulsion of adult worms and vaccination designed to halt reinfection would offer the most effective means of control.
The boisterous young women had come along to receive an extra treatment – a vaccination designed to protect them, and any soon-to-be-born babies they might be carrying, against the scourge of maternal and neo-natal tetanus.
Vaccine design and vaccination strategy against influenza in these populations warrant further studies.
Therefore it was considered acceptable to proceed with a Phase 1 study with staggered vaccinations, designed to allow safety assessment prior to the next dose cohort and minimize the number of severe adverse events.
Most cases of malaria occur among children living in sub-Saharan Africa, a region where many receive routine vaccinations designed to prevent other diseases; for example, 75% of children in sub-Saharan Africa receive measles vaccines.
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