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We compared γδ T cells expanded by BP3 peptide or OXYS protein obtained from un-vaccinated persons and BCG vaccinated persons.
OPV protects vaccinated persons directly and also protects other susceptible persons who are indirectly "vaccinated" as the vaccine virus spreads in the community.
Twenty previously vaccinated persons were included to monitor possible trends in interference of neutralizing antibodies in yellow fever vaccination.
Percentage of BCG vaccinated persons.
We excluded data sets involving vaccinated persons wherever possible.
Among older (mostly vaccinated) persons, the increase in hospital admissions was relatively small.
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Because antigens within PPD are also found in other mycobacteria, the TST suffers from poor specificity in bacille Calmette Guérin (BCG -vaccinated persons.
Previous BCG vaccination; a meta analysis reported increased likelihood of a positive TST in BCG-vaccinated persons within the first 15 years after vaccination [ 27].
Furthermore, the new vaccine can stimulate immunity even in non-vaccinated persons that live in close proximity to those who are immunized, which results in broader community protection.
The model was estimated using published sources and includes indirect (herd) protection of non-vaccinated persons.
Indeed, it has been shown in previous studies that both humoral and cell-mediated immune (CMI) responses may contribute to protection in influenza-vaccinated persons.
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