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Although the oral rabies vaccine is sufficient to induce herd immunity inside the vaccinated area, it simultaneously creates a demographic refuge.
The vaccinated area is compact around the detected outbreak and implemented in the model as a solid square.
In all scenarios we found noteworthy frequency of rabies infections spreading beyond the vaccinated area (Fig. 6a).
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Comparison of the incidence of meningitis in the 3 regions where PsA-TT campaigns had taken place with the areas that had not been vaccinated showed that the epidemic had been halted in the vaccinated areas, as well as a statistically significant difference between areas in the incidence of all cases of meningitis of 94% [ 5].
The World Health Organization then asked Dr. Horstmann to study the incidence of polio in the vaccinated areas.
The main objective of the present study was to analyse, by using DNA microarray, whether the loss of genes in Bordetella isolates was specific either to a special area of the world or to certain PFGE groups, or whether this represents a general feature of the recent isolates circulating in vaccinated areas of the world.
The 3 sizes of vaccinated areas (PVacArea) remain constant throughout a simulation run.
Cases of meningitis declined dramatically in vaccinated areas, but an epidemic continued in the rest of Chad.
The conditional exact test (CET) was used to estimate the risk of an adverse event in individuals in the vaccinated areas compared with individuals in unvaccinated areas experiencing an event during the predefined risk window.
Third, the occurrence of cases in areas >5 km away from villages vaccinated in the previous year suggests that targeting vaccination to areas within a 5-km radius of reported KFD activity may not be effective in preventing KFDV transmission outside the vaccinated areas.
During the 2012 meningitis season, the incidence of meningitis decreased by >90% in vaccinated areas compared with the rest of the country, and a similar reduction in the incidence of carriage of serogroup A Neisseria meningitidis was found, as reported previously (4 ).
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