"There are only vacant lots in pockets, maybe two or three on a block -- and there are well-established neighborhoods, where here we need to create that.
The crystal structure of the SAM-depleted enzyme exhibits a vacant SAM-binding pocket, with a conformation identical to that of the SAM-enzyme co-crystal structure.
Ligand flux in hDHFR is thought to be mediated by conformational changes between a hinge-open state when the substrate/product-binding pocket is vacant and a hinge-closed state when this pocket is occupied.
FIVE years ago, most developers shied away from this economically struggling city with its half-filled office buildings and pockets of vacant storefronts.
The primary conformational change that hDHFR undergoes as it progresses through the catalytic cycle is between a hinge-closed state, in complexes where the substrate or product is bound, and a hinge-open state, formed when the substrate or product binding pocket is vacant, i.e., in the E NADPH complex.
In spots Mumbai is an anarchic jumble, its high-rise buildings flanked by vest-pocket slums and vacant properties that have reverted to near-wilderness.
Schaub doesn't step up in the middle of the pocket when it's vacant, and he frequently underthrows balls when rushed up the middle.
In fact, there is extra vacant space within the Site II pocket immediately above the di-copper center (Fig. 3b).
In the FGFR4K FIIN-2 structure, the hydrophobic pocket (site 3) that becomes vacant upon outward flipping of the DFG phenylalanine remains unutilized.
Desirable pockets in affluent cities like Scottsdale have little vacant space available at any price, while areas close to the downtown core and along established urban corridors are weathering the storm fairly well.
Between old warehouses in the midst of becoming trendy lofts and cranes in vacant lots pulling up high-end glass condos are growing pockets of refined taste and class.
