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Although regenerative medicine utilizing tissue scaffolds has made enormous strides in recent years, many constraints still hamper their effectiveness.
Though much progress in utilizing tissue engineering technology to investigate tumor development in vitro has been made, the effective management of human melanoma is still a challenge in clinic due to lack of suitable 3D culture systems.
This success, obtained utilizing tissue cultures, encouraged a number of organizations to support research on these parasites in an accelerated effort to develop field vaccines.
Previous studies utilizing tissue recombination with seminal vesicle (SV) mesenchyme and prostatic ductal tips from wild type and ERαKO mice suggested that both epithelial and stromal ERα are necessary for SQM.
Observational studies utilizing tissue biomarkers of n-3 fatty acids, the reductions in risk are even larger.
Mothersill and colleagues have investigated the communication of bystander signals in vivo, utilizing tissue explant techniques (Mothersill et al. 1990; Mothersill 1998; Mothersill et al. 2001).
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Utilizing tissue-relevant ECM coatings for neuronal cultures allows accelerated network formation and maturation within two weeks (rather than four weeks in the absence of ECM), thus providing the means to increase throughput of functional compound screening applications.
Furthermore, studies utilizing tissue-specific expression systems have revealed a vital role for miRNAs in the development of specific organ systems (reviewed in [8]).
Utilizing tissue-specificity information from UniProt, Recon 1 was filtered to draft network reconstructions of the human hepatocyte, adipocyte, and myocyte.
This reveals clues to the high tissue specificity of the anti-filarial worm immune response in Ar. subalbatus (Fig 5), and emphasizes the value of utilizing tissue-specific probes to conduct microarray studies.
PPARγ is an important regulator of adipose tissue development, fatty acid synthesis and insulin sensitivity of major glucose utilizing tissues.
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