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Similarly MAPKs are also contain short docking site that recognizes many downstream target proteins by utilizing the same strategy.
HNEA was synthesized by simple hydrolysis of ester 7. The carboxy analogues were synthesized utilizing the same strategy as that in HNE synthesis (Scheme 3).
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He is expected to utilize the same strategy in Afghanistan.
Such tools, which utilize the same strategy for different kinases, may inadvertently miss elements of substrate recognition that are in some way unique to a particular kinase system.
Similarly, to determine the effect of ubiquitylation on VHL protein stability, we utilized the same strategy along with or without treatment with the proteasomal inhibitor MG132 to test the stability of wild type VHL and its ubiquitylated-site specific mutants (K171R or K196R).
Ct-based quantification can utilize the same strategy if Ct values are converted into F0.
Thus, while the spatial working memory system in MG rats may have been impaired, they seemed to be utilizing the same spatial strategy.
For all the transgene constructs (Trpc6-wild type, Trpc6-HA P111Q and Trpc6-HA E896K) the CMV promoter was replaced with the human podocin promoter (NPHS2) [20] (kindly donated by Dr. Holzman) utilizing the same two step strategy.
With such a large number of market participants all utilizing the same technologies and strategies, there is an obvious mechanism for systemic risk to be created.
It's often the case that companies attempt to utilize exactly the same strategy regardless of the platform they are operating on.
It would appear that the constraints of the genetic approach imposing secondary structure on the targeting peptide may have reduced the affinity of the selected peptide for the target receptor, although previous strategies utilizing the same approach have yielded success.
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