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Recently, David et al. [ 117] utilizing the mouse model of anxiety/depressive-like state induced by chronic corticosterone treatment contributed to a better understanding of the link between antidepressants and hippocampal neurogenesis.
Our work utilizing the mouse model for a thorough functional study has provided clear genetic evidence showing the essential role of STAT5 in GM-CSF and IL-3 production in this novel TH cell subset.
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To gain further physiological insight into furin function in mammalian placentation and pregnancy, we utilized the mouse model.
We therefore compared the influences of bmMSC, VEGF and a combination of both on the early processes of vascularization, utilizing the mice skinfold chamber model and intravital fluorescence microscopy.
Utilizing the established mouse model of colonic inflammation, the IL-10−/− mouse [19] [21], we compared the incidence of epithelial cell fusion in mice transplanted with green fluorescent protein (GFP -expressing GFP -expressingowholeM) with those treated with the anti-inflammatory drug, 5-aminosalicylic acid (5-ASA), or to wild-type (WT) transplanted mice (Figure 1A).
Utilizing the HD mouse model that expresses mhtt in the MSNs of the striatum but not in the cortex or glia, we demonstrate that increased sensitivity to QA excitotoxicity in young, presymptomatic mice has a largely non-cell autonomous component and the increased resistance to excitotoxic insult observed in older symptomatic HD mice can be primarily attributed to cell-autonomous effects of mhtt.
Hypothesis generation is performed automatically by a computer program that utilizes the mouse knowledge assembly model to identify hypotheses that explain the input RNA state changes, prioritized by multiple statistical criteria.
We utilized this mouse model to test the hypothesis.
In the second model, we utilized the HHD mouse model as a platform for active antitumor immunization.
The JNPL3 mouse model utilizes the mouse prion promoter [ 5] to drive mutant human tau expression [ 31].
To model HD, we utilized the N586-82Q-C63 mousexpressingpressing 586 amino acids of an N-terminal fragment of huntingtin containing 82 glutamine repeats, hereafter termed HD586-82Q.
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