Sentence examples for utilizing mouse models of from inspiring English sources

In our attempt to obtain further in vivo evidence of caspase-4 down-regulation mediated by an FE65/Teashirt complex, we encountered the difficulty that the CASP4 gene was not represented in the mouse genome (discussed further below), preventing us from utilizing mouse models of AD as well as knockout mice.

We have utilized mouse models of mammary tumorigenesis to examine the role of integrin α6β4 signaling in tumor progression in vivo.

The two most commonly utilized mouse models of juvenile CLN3 disease are Cln3-knockout (Cln3−/−) and Cln3 Δex7/8-knock-in mice.

The two most commonly utilized mouse models of juvenile CLN3 disease are Cln3-knockout (Cln3−/−) and Cln3 Δex7/8-knock-in mice, the latter mimicking the most frequent disease-causing human mutation.

Results The two most commonly utilized mouse models of juvenile Batten disease are Cln3-knockout (Cln3−/−) and Cln3 Δex7/8-knock-in mice, the latter mimicking the most frequent disease-causing human mutation.

In the current study, we sought to utilize mouse models of Aβ amyloidosis, tauopathy, α-synucleinopathy, and a polyglutamine disorder (HD) to determine if any aspect of TDP-43 pathology can be driven in vivo by an independent primary pathological aggregate (e.g., tau) caused by a defined genetic event (e.g., mutant tau).

Results Here, the authors explore the possibility of utilizing mouse models to perform a systematic and longitudinal analysis of HCC development.

To utilize mouse models to further characterize the pathogenic mechanisms of airway remodeling and airway hyperresponsiveness in severe asthma.

Cancer biologists utilize several mouse models of cancer (xenografts, syngeneic mice, or genetically engineered mice) to evaluate tumor biology, efficacy, and toxicity of drugs; validate disease pathways; and identify translational biomarkers.

In the absence of an animal model for human AK disease, studies have utilized mouse tumor models of skin cancer and several tumor cell lines.

Another study utilizing a mouse model of graft versus host disease (GVHD) also linked diminished Paneth cell antimicrobials to an increase of normally rare septicemia causing E. coli in expense of symbiotic diversity (Eriguchi et al, 2012).