Sentence examples for utilizing backbone from inspiring English sources

The complex between JAZ ZF3 and a 19 base pair dsRNA, VAIminMut, was modeled using the program HADDOCK utilizing backbone chemical-shift perturbation data from NMR titrations as ambiguous interaction restraints together with general information on protein-binding sites on RNAs.

We developed a method that utilizes backbone cyclization as an intermediate step for conversion of the CD4 noncontinuous active region into small macrocyclic molecules.

We show that the hierarchical LANMAR can incorporate and efficiently utilize backbone links to reach remote destinations (thus reducing the hop distance).

Interestingly, PRMT5 also utilizes several backbone hydrogen bond interactions originating from the main chain of S310, P311, L312, and F580.

The inhibitors were designed having hydrogen bond accepting P2 substituents to probe potential favorable interactions to Asp-29/Asp-30 of the HIV-1 protease backbone utilizing inhibitor 3 as a model template.

Accordingly, a novel subgenomic HCV replicon chimera was created by utilizing a GT1b backbone modified to produce NS5A and NS5B proteins from a consensus sequence generated from HCV GT3a genomic sequences deposited online at the European Hepatitis C Virus database.

The other variant recognizes both LoxP and LoxM7 utilizing the same DNA backbone contact but different base contacts, facilitated by an unexpected DNA shift.

A significant level of signal amplification was achieved by the chain-polymer conjugate technology utilizing enzyme-labeled inert "backbone" molecule of dextran (Dako).

Using curcumin as a lead compound for anti-angiogenic analog design, a series of structurally related compounds utilizing a substituted chalcone backbone have been synthesized and tested via an established SVR cell proliferation assay.

Even though this region of controversial connectivity is quite distant from the anesthetic binding site in question, another model of LyTASK was constructed utilizing the amino acid backbone connectivity corrected to that of 4I9W along with 3UKM as the primary template.

These results illustrate that natural abundance heteronuclear-correlated NMR spectroscopy can be utilized to probe backbone structure and dynamics, and perhaps to map key membrane-binding residues of peptides in complex with micelles.