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In this study, we explored the contribution of c-Jun N-terminal kinases (JNK) signaling to the mesenchymal phenotypes and the aberrant motile capacity of MDR cells utilizing a well characterized MDR cell line KB/VCR, which is established from KB human epidermoid carcinoma cells by vincristine (VCR), and its parental cell line KB.
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As a result, we have tested our hypothesis that PKU may protect against certain kinds of cancers by utilizing a well-characterized PKU mouse model and a 7,12-dimethylbenzanthracene -induced tumor induction protocol.
Utilizing a well-characterized experimental rat cardiac transplantation model, we have shown that allograft viability can be prolonged by direct modulation of host immunity via adoptive T cell therapy using rapamycin-generated Th2-type cells.
We reduced BRD4 expression utilizing a well-characterized siRNA and measured BRD4 mRNA levels via qRT-PCR analysis.
To define the RUNX1/ETO-responsive core transcriptional network and monitor dynamic changes associated with alterations in RUNX1/ETO status, we utilized Kasumi-1 cells, which represent a well characterized and widely used model system for t(8 21) AML (Ben-Ami et al., 2013; Martens et al., 2012; Ptasinska et al., 2012; Sun et al., 2013).
In the present study, we utilized real-time quantitative PCR assays coupled with a novel fluorescent probe known as the molecular beacon to detect the catabolic (iNOS and COX-2) and anabolic (aggrecan and collagen type II) genes utilizing the chondrocyte/agarose model in conjunction with a well characterized bioreactor system [ 40, 41].
This is a well characterized, validated, and reliable immunohistochemical method utilizing a Catalyzed Signal Amplification (CAS) reagent that made HIF-1α nucleus confined detection possible.
αSNAP has a well characterized function in SNARE complex disassembly.
challenge with a well characterized pathogen.
TGFA is a well characterized mammalian growth factor.
HeLa is a well characterized HPV+ cervical cancer cell line.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com