Sentence examples for utilizing a viral vector from inspiring English sources
For this purpose, we stimulated the CDK5 pathway in the adult rat hippocampal NPC model by expressing the CDK5 activator, p35, utilizing a viral vector.
To investigate the role of the CDK5 signaling pathway in the differentiation of NPCs, we studied the effects of activating this pathway in the adult rat hippocampal NPC model by utilizing a viral vector expressing the CDK5 activator, p35.
To deplete GADD34 levels in intact mice, we utilized a viral vector system that delivers RNAi particles of GADD34 into the cerebral cortex.
We have shown significant repression of hepatic ERα activity in mice utilizing Ad.shERα vectors.
Two different shRNAs against Sec61β were individually introduced into COS-7 cells using a viral vector.
Locatelli did not give details on how he cloned the gene into a viral vector in the paper.
Viral vector-associated risk is a major concern in viral vector development, and attenuation is regarded as a desirable feature of a viral vector and efforts are directed toward the development of highly attenuated strains [ 37].
In this kind of gene therapy, siRNA could be delivered into cells utilizing either viral vectors or non-viral carriers, causing degradation of targeted mRNA and subsequently leading to the silence of specific protein expression [7].
siRNAs are introduced into cultured cells directly by transfection or by utilizing plasmid or viral vectors, and similar techniques have been utilized in whole animals, where "naked" siRNA can be delivered to tissues/organs to treat certain disease conditions [30].
At present, to develop the potential therapeutic tools for caner therapy, researchers utilize viral vector system to elevate tumor suppressive miRNAs that eliminate carcinogenesis or anti-miRNA oligonucleotides (to repress the oncogenic miRNAs) which promotes tumorigenesis [ 11].
Previous reports embodying this concept have utilized viral vector systems to deliver human vasoactive intestinal peptide [ 3], IL-27 [ 4], and cytotoxic T-lymphocyte antigen 4 [ 5], each showing beneficial effects upon Sjogren's-like disease in animals models.
