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Utilizing a rat model, this study investigated whether post-weaning exposure to a prototype SSRI, fluoxetine (FLX), influenced performance on visual tasks designed to measure discrimination learning, sustained attention, inhibitory control, and reaction time.
Utilizing a rat model of regional chemotherapy, we evaluated the effectiveness of systemic dasatinib in conjunction with regional melphalan against the human melanoma cell line, DM443, grown as a xenograft.
Standard curves for quantitation of TF levels within the homogenates were generated by spiking known quantities of purified recombinant mouse TF (R&D systems) into each well which was captured utilizing a rat monoclonal anti-TF antibody (generously provided by Daniel Kirchofer, Genentech, San Francisco, CA) and detected utilizing a goat polyclonal anti-TF antibody (R&D systems).
To inactivate Vhl specifically in α-cells, we first generated an α-cell specific Cre transgenic line (Glu-Cre) utilizing a rat glucagon promoter sequence to direct Cre recombinase expression.
Using soluble glycoprotein 130 (sgp130), which binds and inactivates IL-6, Boettger and colleagues made several important findings utilizing a rat model of antigen-induced arthritis.
In this study, we expand on our earlier work to test the effectiveness of simvastatin on disc degeneration utilizing a rat tail disc degeneration model.
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Thus far, the majority of animal studies have utilized a rat model, however, mice may prove particularly beneficial in studying genetic risk factors for developing chemotherapy-induced cognitive impairment.
INTERVENTIONS: We utilized a rat model of cecal ligation and puncture to induce sepsis.
We have previously utilized a rat model of SCI to investigate the temporal changes in tissue composition and mechanical properties in the urinary bladder.
In our laboratory, we utilized a rat surgical model to study BE.
To clarify this issue, we utilized a rat model of unilateral ureteral obstruction (UUO).
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