In conclusion, our data indicate that GLV IRES utilizes a distinctive pathway of recruiting the small ribosomal subunit that does not require a pre-initiation complex.
Here, we investigate the mechanistic rationale for biphasic response to FGFR pathway activation utilizing a combination of high-density signaling data and Ordinary-Differential-Equation (ODE -based mathematical mODE -based
The regulation of lipid metabolism is a very complex process, utilizing a number of signals and pathways leading to lipid synthesis, breakdown or both [2].
All P values for these genes were significant after a FDR adjustment within the confines of this pathway ANOVA utilizing a pre-defined subset of genes meant to address a specific question about sulfur-utilization and glucosinolate biosynthetic pathways.
We have constructed various mutants in the C-terminal redox center of mouse TR3 and PfTR and show that these enzymes can utilize a catalytic pathway that is independent of the C-terminal redox center for the reduction of various small molecule substrates.
Ancient organisms that incorporated cysteine into polypeptide chains took advantage of this pathway, while in the modern world, the majority of organisms utilize a standard pathway involving class I CysRS.
In order to investigate this pathway utilizing a more physiologically relevant model of ERα-positive breast cancer, we employed MCF7 cells, which express both ERα and GPER.
Arsenate resistance seems to be a highly plastic process in which organisms can utilize a variety of pathways to perform the necessary reduction reaction.
The pathway utilizes a subset of recombination proteins (Rad51, Rad55, Rad57, Exo1 and Rad59) and both replicative polymerases, Pol ε and Pol δ (Vanoli et al. 2010).
Taken together, these results indicate that α4β1 outside-in signalling leads to the phosphorylation of the TCR ESC proteins Lck, ZAP-70, Vav1, SLP-76 and LAT and therefore this pathway utilizes a subset of proteins common to TCR signalling.
To evaluate whether MSA is utilizing VHL independent pathway of degradation of HIF-1α, FaDu cells which express wild type VHL were used to knockdown VHL by siRNA.
