Utilizing a next-generation sequencing screening platform and an adaptive umbrella trial design, we will explore the activity of multiple biomarker/targeted therapy options in order to expand the precision medicine opportunities for patients with non-small-cell lung cancer.
In this study, we utilized a prototypic next generation Hsp90 inhibitor, EC154, representing a novel synthetic compound with enhanced potency and diminished toxicity relative to 17-AAG.
The modelling technique was used to generate an actuator design that will utilize the available power more efficiently in a next generation pumping device.
We describe a method utilizing next generation sequencing to score SNPs and anchor assemblies to a genetic map by exploiting the bin mapping strategy, hereafter referred to as the SNP by Sequencing Bin Mapping strategy (SSBM; Figure 1).
Utilizing a high-resolution next generation sequencing approach we sequenced the Chinese hamster mitochondrial genome for the first time and surveyed the mutational landscape of CHO cell mitochondrial DNA (mtDNA).
These problems can be avoided by utilizing Next Generation Sequencing (NGS), a high-throughput sequencing methodology which generates millions of sequences simultaneously from one sample [ 8].
According to DNA DTC, the company offers a range of products "utilizing next generation sequencing including the entire exome (at 80x coverage) and the whole genome". The company's website, while fairly Spartan, appears to bear this out.
We developed a genome-wide approach to link genotype to clinical outcome by consecutively utilizing next generation sequencing and gene chip data of 6,697 breast cancer patients.
However, utilizing next generation sequencing to perform such studies poses numerous challenges.
By utilizing Next Generation Sequencing, our studies characterized the complete miRNAome and its editing in vivo during prepubertal testicular development.
For example, several groups are utilizing next generation sequencing technology for whole-genome sequencing of primary tumors and matched metastases [ 63, 64].
