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An endotracheal tube was inserted into the trachea and artificial respiration with ambient room air was employed utilizing a large animal ventilator (Harvard Apparatus, Boston, MA, USA).
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However, a major advantage of utilizing a larger animal, such as the sheep, for lymphedema studies is that lymphatic function can be measured, something that is extremely difficult to achieve in a small species.
Thus, in consideration of clinical relevance, it is preferable to utilize a large animal model to investigate the influence of maturity on the results of cell-based therapies to repair chondral lesions.
For these experiments, a large animal model was utilized as a bridge to translation since it enabled the use of catheterization techniques and imaging equipment employed in the clinic.
The current study also aims to create a large animal model for osteomyelitis and the evaluation of antimicrobial coated intramedullary nails utilizing a goat tibia osteotomy model.
A large animal model of grade V liver injury combined with hypothermia and hemodilution was recently utilized to demonstrate the effectiveness of rFVIIa when used as an adjunct to gauze packing.
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We utilized a large Angus-sired population to calculate genomic breeding values of individual animals and to identify genomic regions harboring genetic variation associated with fatty acid composition.
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