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Recently, a study by our group, utilizing a high throughput mitochondrial sequencing array for the entire mitochondrial genome has demonstrated a 49% of incidence of mitochondrial mutation in head and neck squamous cell carcinoma in another limited cohort [27].
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In this study, we utilize a high throughput screening (HTS) methodology to rapidly study the nature of the co-catalyst with an emphasis on combinations of metal co-catalysts that appear to work in a synergistic manner to increase palladium usage.
We have utilized a high throughput nano-fluidic PCR approach to analyze individual worm miRNA expression profiles, in order to assess age-dependent differences and between-worm variance in miRNA abundance.
Here we utilized a high throughput loss of function approach using siRNAs to identify genes whose inhibition would synergize with topotecan with the ultimate goal of discovering potent synergistic drug combinations for treating patients with neuroblastoma.
Here we present the results of a prospective study utilizing a high-throughput miRNA microarray analysis in which a miRNA expression signature has been identified that distinguishes gastric cancer from normal stomach epithelium.
These various orientations could be explored by mutating the appropriate amino acid side chains (to relieve putative steric clashes) and by utilizing a high-throughput coupled assay to test each mutant for its ability to convert FP to FPP.
Our understanding of the relationship between human distal gut microbiota and cirrhosis was based mainly on the results of culture-based studies until recent initiatives utilizing a high-throughput sequencing approach [ 10, 11], which made it possible to characterize significant cirrhosis-related alterations in the microbiota community and functions in the present study.
In order to improve cisplatin response in ovarian cancer cells, we utilized a high-throughput RNAi screening to identify kinase modulators.
Since TAS2R9 was an orphan receptor, we utilized a high-throughput screening strategy to identify bitter-tasting stimuli that activate TAS2R9.
To identify novel epigenetic markers of aggressive bladder cancer, we utilized a high-throughput DNA methylation bead-array in two distinct population-based series of incident bladder cancer (n = 73 and n = 264, respectively).
For DNA methylation analysis, we have utilized a high-throughput methodology, recently developed in our laboratory.
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