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Recently Freitas et al. have reported changes in the myocardium utilizing a high dose of thyroxine (600 μg/kg/day which corresponds to 150 μg/d per animal having a weight of 250 g).
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Based on the results from this study, a trial in patients with HER2+ breast cancer utilizing a higher dose of retaspimycin HCl is warranted.
In this study, we utilized a high dose of STZ to induce the diabetic model.
It was Haldol at a high dose, and nothing else.
Plus, a high dose of antibiotics.
It contains a high dose of levonorgestrel, the same hormone used in many birth control pills.
The old theory was that if a high dose of a toxic substance causes cancer in lab studies, then lower doses were safe.
"NBC contacted the Metropolitan Police Department inquiring if they could utilize a high capacity magazine for this segment.
The published experience with posterolateral fusion, although encouraging, utilizes a significantly higher dose and concentration of recombinant human bone morphogenic protein-2 (rhBMP-2) and a different carrier than the commercially available INFUSE.
Alternatively, since we utilized a dose higher than that used in the haploid screen (50 and 25 µg/ml as compared to ∼11 µg/ml), this may have allowed the identification of more DOX resistance genes.
Women, perhaps, could hazard a higher dose.
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