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Transcriptional control of a gene is often studied by utilizing a fusion of the gene's promoter with a reporter gene [chloramphenicol acetyRransferase (CAT), green fluorescent protein (GFP), and so on].
We hypothesize that this resulted from efficient antigen capture via BLyS specific receptors and subsequently improved antigen presentation and T cell costimulation, as has been shown for a model system utilizing a fusion of antigen to IL-2 [ 25].
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To summarize, we utilized a fusion of "old school" physical mapping with ultrahigh throughput pyrosequencing to sequence an ~18-Mb chromosome arm in a single experiment.
A similar approach utilizes a fusion of the same antibody binding domain with Sindbis envelope glycoproteins [ 32].
It has been demonstrated that the tropism of MV can be retargeted to many different cell surface molecules by utilizing a fusion protein consisting of single-chain antibodies (scFv), peptides, growth factors or cytokines fused to the extracellular C terminus of the H protein [ 23].
Thus our lab previously developed a system utilizing a fusion protein, LFnBLA, consisting of the N-terminal region of LF (LFn) and β-lactamase (BLA), which together with the substrate coumarin cephalosporin fluorescein acetoxymethyl ester (CCF2/AM), allows imaging of the toxin delivery into cells [25].
A two-step transcriptional amplification (TSTA) system has been described which utilizes a Gal4-VP16 fusion protein instead of tTA for amplification of gene expression [ 13- 17] and is similar to our previous PS/TR system [ 9].
She utilizes a unique skill set that is a fusion of her English major and MBA, brand strategist role and teaching experience, writing philosophy and hybrid thinking approach.
ACSEA utilizes a logic-based data representation model and a fusion of inductive logic reasoning and statistical inference in the general framework of AEA.
Sipuleucel-T (APC8015 or Provenge) is a novel cancer immunotherapy, which utilizes a recombinant fusion protein (PA2024) consisting of granulocyte macrophage colony-stimulating factor and prostatic acid phosphatase to stimulate the patient's T cells response [ 140].
What is the Fusion a fusion of?
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