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Utilizing a candidate gene association approach, we genotyped 21 SNPs within and around MECP2 in SLE patients and controls.
Utilizing a candidate gene approach, we first identified significant association with MECP2 SNPs and SLE in a cohort of Korean SLE patients and controls.
An important task for a genetic epidemiologist utilizing a candidate gene approach is the selection of appropriate genes and SNPs for testing the disease association.
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Second, most association studies to date have utilized a candidate gene approach, in which we are limited by our biologic knowledge.
We utilized a candidate gene approach to evaluate the association between genetic polymorphisms and the risks of developing cachexia in patients recruited across three centres.
Pharmacogenetic research focuses therefore on identification of specific genes that influence drug response by utilizing a candidate-gene approach [10], [11], although supporting evidence for a role of these genes in development of obesity and associated metabolic traits from population-based observational studies is sparse.
This study has demonstrated how integrated genomic resources can be utilized for a candidate gene approach.
A candidate gene approach was utilized to map the W locus in the two-part pedigree described above.
Whole genome approaches have utilized genome-wide association studies (GWAS) to reveal loci not predicted on the basis of a candidate gene, but it remains difficult to locate causative genes and susceptible loci were not always replicated.
a Candidate gene prediction of qCTS3-9.
A candidate gene association study is a general approach to identify susceptibility genes.
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