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Alternatively, these data may suggest that negatively correlated ST3GAL6, which utilizes the same substrate as fucosyltransferases, may compete with the biosynthesis of this epitope by prior sialylation of the fucosyltransferase substrate(s).
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These observations strongly support the contention that all enzymes encoded by the genes included in these analyses bind and utilize the same substrate, phenylalanine.
Unlike heterotrophic organisms that utilize the same substrate as the source of both carbon and energy, photoautotrophic organisms require two substrates, one for energy (light) and one for carbon (carbon dioxide).
We note that this previously unreported site utilizes the same residues that coordinate an invariant P-3 Arg residue from substrate and inhibitor peptides (24).
The album cover utilizes the same design as the novel.
As another means of probing the selectivity of the candidate APE1 inhibitors (Figure 3), we miniaturized to a 1536-well format a qHTS assay for E. coli EndoIV [19] utilizing the same THF-containing red substrate as above (Figure S3).
Birds, Jarvis explains, "have a cortical region that developed, in fact, from the same substrate as in humans".
Specimens of epiphyllous liverworts consisting of multiple taxa on the same substrate (leaf) contain multiple barcodes.
Moreover, the utilization of a dedicated transport adaptor may also ensure that the cargo proteins do not stand in competition with other import substrates that utilize the same generic transport receptor.
Such tools, which utilize the same strategy for different kinases, may inadvertently miss elements of substrate recognition that are in some way unique to a particular kinase system.
To test the specificity of α-syn ubiquitinylation by CHIP in our system, we examined two other E3 ubiquitin ligases, HDM2 [39] and MuRF1 [40], which utilize the same UbcH5 family of E2s as CHIP to mediate the ubiquitinylation of substrate proteins.
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