Recently, David et al. [ 117] utilizing the mouse model of anxiety/depressive-like state induced by chronic corticosterone treatment contributed to a better understanding of the link between antidepressants and hippocampal neurogenesis.
Our work utilizing the mouse model for a thorough functional study has provided clear genetic evidence showing the essential role of STAT5 in GM-CSF and IL-3 production in this novel TH cell subset.
In the second model, we utilized the HHD mouse model as a platform for active antitumor immunization.
To model HD, we utilized the N586-82Q-C63 mousexpressingpressing 586 amino acids of an N-terminal fragment of huntingtin containing 82 glutamine repeats, hereafter termed HD586-82Q.
To evaluate the therapeutic efficacy of bioreactor-derived iPSC-Mac in vivo, we utilized the humanized mouse model C 129S4-Rag2tm1.1Flv Csf2/Il3tm1.1 CSF2,IL3 Flv Thpotm1.1 TPO FlvThpotm1.1(TPO)Flv Il2rgtm1.1Flv Tg(SIRPA)1Flv/J (hIL-3/GM-CSF KI), an immunodeficient strain with impaired alveolar macrophage development and an established model to study pulmonary infections19,20,21.
In order to further study the possible role of IL-6 in mediating muscle damage, these investigators utilized the mdx mouse model of DMD.
We utilized this mouse model to test the hypothesis.
Accordingly, we utilized this mouse model to determine if HIV-Tat protein is sufficient to alter the behavioral effects and rewarding properties of a commonly abused psychostimulant, cocaine.
While only few studies have so far utilized the ARKO mouse models, in the future these models (both global and cell-specific ARKO) combined with various transgenic experimental breast cancer models may be uniquely enlightening when exploring the cell-specific role of AR as well as the influence of AR-mediated androgen actions on specific carcinogenic pathways.
Hypothesis generation is performed automatically by a computer program that utilizes the mouse knowledge assembly model to identify hypotheses that explain the input RNA state changes, prioritized by multiple statistical criteria.
