The strongest evidence for this conclusion comes from studies utilizing rodent models of colitis [ 8, 10] and is also supported by clinical observations [ 5, 6].
To date, most of the work that has been performed so far has utilized rodent models, most likely due to the availability of transgenic mice and the extensive knowledge of mice genetics and biology that exists.
The importance of utilizing human cells for these purposes is evident by the large number of drugs that show efficacy and safety in rodent models of diseases but subsequently fail in human clinical trials, which are partly attributed to these species differences (Rubin, 2008).
Rodent models of epilepsy reveal similar patterns of glutamate overflow.
Rodent models of sepsis are frequently used to investigate pathophysiological mechanisms and to evaluate putative therapeutic strategies.
Small animal positron emission tomography (PET) is a frequently used methodology to investigate rodent models of healthy and diseased states.
Marvelous whole body amelioration has been achieved in rodent models of many diseases.
FGF21 reduces glycemia and lipidemia in rodent models of obesity and type 2 diabetes.
Rodent models of osteoarthritis and rheumatoid arthritis are useful tools to study these disease processes.
The compound (R --10e also showed excellent efficacy in R --10et R --10emodels of neuropalsoc pain.
