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Multivariate methods were utilized in a screening design with several responses of a tablet formulation.
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A luciferase-based reporter gene assay was utilized in a high-throughput screening program conducted under the NIH-sponsored Molecular Libraries Probe Production Center Network program to identify the active scaffolds.
For instance, He et al. attained good results by employing a molecular dynamics simulation to obtain an altered conformation of the 3D-structure of mPGES-1, which was modified towards an active state conformation and utilized in a docking-based screening strategy.
The unexpected promiscuity of CYP51 revealed by target-based screens may potentially be utilized in a piggyback strategy for identifying a chemical starting point (e.g., glutamyl-peptidyl cyclotransferase inhibitors) for antiparasitic therapy development, while structure activity relationships derived from parasite assays could lead to disease-specific clinical candidates.
We thus sought to identify phenotypes that we could utilize in a tractable screen for second-site suppressor mutations.
With a reliable model of PI3Kα in hand, docking could be well utilized in future screening campaigns for isoform selective compounds.
The validated pharmacophore was utilized in database screening to identify potential hits.
Full factorial design and central composite design (CCD) from the response surface methodology (RS M were utilized in the screening and optimization of the system.
Full 24 factorial design and the response surface methodology using central composite design (CCD) were utilized in the screening and optimization of this study.
Finally, it must also be considered that we used film-screen mammography, which is no longer considered the state-of-the art technique, despite still being utilized in many screening programs.
Gloss has already been utilized for the description of coated tablet [5], but as far as we know, it has not be utilized in the screening of counterfeit tablets.
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