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In order to address the issue of systemic toxicities, our prior research has focused on the development of a micro particle (1 – 3 μm diameter) that can be utilized for targeted drug delivery due to its porous nature [11].
Enzymatically degradable hydrogels also have been utilized for targeted drug delivery since the concentration of enzyme is dependent upon cell and tissue types, enabling local triggered drug release.
Among targeting agents directed to the membrane-bound and tumor-associated receptors, folate (FA) has been widely utilized for targeted delivery of drug-loaded nanoparticles into FR+ tumor cells as a ligand for a folate receptor (FR) overexpressed in a wide range of tumors including those of the ovary, brain, kidney, breast, and myeloid [16 18].
The same sst2 ligands coupled to β-emitters 90Y or 177Lu are successfully utilized for targeted radionuclide therapy, peptide receptor radionuclide therapy (PRRT) comprising a well-established, effective systemic treatment modality in patients with inoperable, metastatic gastroenteropancreatic NET GEP NETT) [8 11].
They are utilized for targeted imaging by magnetic resonance imaging (MRI), single photon emission computed tomography (SPECT), positron emission tomography (PET), computed tomography (CT), photo acoustic imaging (PAI), two photon or fluorescent imaging and ultra sound etc. Toxicity factor of NPs is also a very important concern and toxic effect should be eliminated.
Thus, PS-coated SWCNT can be utilized for targeted delivery of specialized cargos - regulators, inhibitors - into macrophages to control their functions including inflammatory responses to SWCNT themselves.
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Molecular hybridization as a tool has been particularly utilized for targeting tubulin protein as exemplified through the number of research papers.
Both synthetic and natural nanoparticles such as polymeric conjugates, liposomes, micelles, and polymeric nanoparticles, and synthetic organic nanoparticles such as carbon nanotubes, polyhydroxylated fullerenes, dendrimers, inorganic nanoparticles of gold, silver and iron oxide, quantum dots, viral capsids and ferritin have been utilized for targeting angiogenesis.
This aggregation is being utilized for targeting systemically delivered ELP drug conjugates to heated tumors.
It is conceivable that anti-EpCAM-conjugated nanoparticles loaded with cancer drugs could be utilized for targeting CTCs of epithelial state in blood.
Such knowledge can be utilized for target marketing or grouping similar, yet distinct, nodes.
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