Using this structural information, we have utilized a structure-based rational design approach to stabilize the α-helical structure of CAI and convert it to a cell-penetrating peptide (CPP).
We utilized a structure-based approach to design a novel RTK inhibitor, MP470, which effectively inhibits PDGFR, c-Kit and c-Met.
Utilizing a structure based design approach, combined with extensive medicinal chemistry execution, highly selective, potent and novel BACE1 inhibitor 8 (BAlphaassay assay IC50 = 8 nM) was made from a weak μM potency hit in an extremely efficient way.
The structure of coming in daily allowed him to utilize a structure and find a balance between academics and social opportunities.
However, rather than utilize the MFE structure of our initial sequence as the reference structure, we utilize a structure that is derived from a multiple sequence alignment (MSA) of homologous RNAs to more accurately reflect the biologically relevant structure [ 41].
Second, we utilize a structure derived from comparative genomics as the reference structure T rather than the M F E(e(S)).
We will utilize a structured, proven approach for writing manuscript sections and aspects of clear writing that often plague inexperienced and even experienced manuscript writers.
We have been able to identify 24 novel BRAF kinase inhibitors with Kd values ranging from 0.4 to 10 μM utilizing a structure-based de novo design method with the two known inhibitor scaffolds.
Other new improvements include adopting a new method to more accurately describe and analyze the effects of the higher-order J2 perturbation, combining all the uncertainties into a diagonal structure, and utilizing a structured singular value to synthesize and analyze the controller.
The researchers collected data between May 12 , 2009 and March 22 2010 utilizing a structured and modified exclusive breastfeeding attrition prediction tool.
The BEL framework is an open-source technology for managing, publishing, and utilizing a structured life-science knowledge (http://www.openbel.org/) [ 25].
