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In this study, we utilized a mouse tibia injury model, single-photon emission computed tomography (gamma scintigraphy or SPECT), ex vivo micro-computed tomography, and histology to monitor 99mTc-MDP uptake in injury sites during skeletal healing.
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To further study the role of IL-25 in breast cancer development, we utilized a mouse model of spontaneous breast tumor - the MMTV-PyMT transgenic mouse.
In this study we addressed a question: Does a mouse tibia flown in space show altered levels of eIF2α-p?
To investigate the influence of mutationally activated Met in tumorigenesis, we utilized a novel mouse model.
The current study also aims to create a large animal model for osteomyelitis and the evaluation of antimicrobial coated intramedullary nails utilizing a goat tibia osteotomy model.
To examine Isl1 function in stomach development, we utilized a tamoxifen-inducible knockout mouse model.
In contrast, a recent experiment using the mouse tibia suggested that there was a negative interaction between zoledronic acid and mechanical loading in cortical bone [28].
The surgical approach utilized a longitudinal medial incision over the distal thigh extending medially toward the ankle and following the juncture of the anterior compartment with the tibia.
This experiment utilized an FVB-transgenic strain of mice where eGFP identifies GABA neurons.
Each potted mouse tibia specimen was placed horizontally into a uniaxial test frame to prevent gravitational loading of the specimen by the PMMA endcaps [46].
The effect of clodronate on periosteal apposition was increased when combined with mechanical loading in the rat tibia [25], whereas a recent study suggested that zoledronic acid impaired cortical bone's response to loading in the mouse tibia [28].
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