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To further evaluate the critical role of ADAM family proteases in IL-6Rα shedding, we also utilized a more specific protease inhibitor, TAPI-2, an inhibitor of ADAM family proteases including ADAM17.
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The amygdala was part of the general EMO mask, but the additional analyses focused exclusively on amygdala and rACC regions, and as such utilized a more liberal corrected threshold specific to the size of each ROI (i.e., small-volume correction).
Moreover, our efforts in utilizing bioinformatics methods to prioritize good candidate genes provided a more specific set of putative candidates.
In contrast, the newer generation of microarrays from Affymetrix utilizes a whole-transcript amplification protocol and an exon-based probe design, which may offer a more specific portrait of expressed sequences [32].
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