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We have utilized a high throughput nano-fluidic PCR approach to analyze individual worm miRNA expression profiles, in order to assess age-dependent differences and between-worm variance in miRNA abundance.
Here we utilized a high throughput loss of function approach using siRNAs to identify genes whose inhibition would synergize with topotecan with the ultimate goal of discovering potent synergistic drug combinations for treating patients with neuroblastoma.
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In this study, we utilize a high throughput screening (HTS) methodology to rapidly study the nature of the co-catalyst with an emphasis on combinations of metal co-catalysts that appear to work in a synergistic manner to increase palladium usage.
Recently, a study by our group, utilizing a high throughput mitochondrial sequencing array for the entire mitochondrial genome has demonstrated a 49% of incidence of mitochondrial mutation in head and neck squamous cell carcinoma in another limited cohort [27].
In order to improve cisplatin response in ovarian cancer cells, we utilized a high-throughput RNAi screening to identify kinase modulators.
Since TAS2R9 was an orphan receptor, we utilized a high-throughput screening strategy to identify bitter-tasting stimuli that activate TAS2R9.
To identify novel epigenetic markers of aggressive bladder cancer, we utilized a high-throughput DNA methylation bead-array in two distinct population-based series of incident bladder cancer (n = 73 and n = 264, respectively).
For DNA methylation analysis, we have utilized a high-throughput methodology, recently developed in our laboratory.
To experimentally investigate the functional differences of the two mitotic modules suggested by our computational analyses, we utilized a high-throughput RNAi-based cell spot microarray screening method [ 25].
A recent study by Guo Wei and colleagues utilized a high-throughput screening method to analyze a library of compounds, to identify those that preferentially repress MCL1 expression [ 1].
Method development utilized a high-throughput orthogonal-array-optimization, and two sensitive and stable signature-peptides (SP) from different domains were selected based on extensive evaluations in plasma matrix.
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