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One early work on myocardial hypertrophy following thyroxine administration utilized a dose of 250 μg/kg body weight s.c. per day.
In our study, we utilized a dose of 1 mg/kg body weight/d, a dose far lower than the reported maximum safe dose and one that has been previously tolerated without side effects (24 – 24).
A preoperative window of opportunity trial in breast cancer patients utilized a dose of 2000 mg/day [ 24], whereas the ongoing NCIC CTG MA32 phase III clinical trial is testing the effect of adjuvant metformin, is utilizing a dosage of 1700 mg/day.
We utilized a dose of 12 mg/kg/day in order to obtain a similar reduction in blood pressure as is achieved using losartan in our Marfan mouse model, as we wished to eliminate blood pressure as a confounding variable when comparing the differential physiological and biochemical effects of the two agents.
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A Phase II clinical trial utilizing a dose of 3 g/day in subjects with DPN is ongoing.
The final concentration of this solution was 3 mg/mL and utilized a dose volume of 1.0 mL/kg with a target radioactivity of 50 μCi/rat.
Subsequent experiments utilized a radiation dose of 6 Gy because the percentage of cells remaining after 8 Gy SMMC-77211: 0.9-4%; BEL-7402: 2-5%) was too low for analysis.
These neutral studies utilized a total dose of IsoBicarb that was lower (less than 1.5 mEq bicarbonate/kg) than the dose in those studies that showed statistically significant benefit (more than 1.5 mEq bicarbonate/kg).
Previous nuclear imaging studies with fibrin binding peptides utilized a probe dose of about 1 nmol peptide.
In this study, we utilized a high dose of STZ to induce the diabetic model.
We therefore utilized a single dose of 15 nmol in all animals, enabling an accurate comparison across ages and genotypes.
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CEO of Professional Science Editing for Scientists @ prosciediting.com