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The constructs utilize the mouse Plp1 promoter and associated sequences to drive expression of the lacZ reporter gene.
Effective cancer research should take advantage of the opportunity to utilize the mouse as a genetically, microbially, and environmentally standardized animal model system, but this requires global awareness of the biology of the laboratory mouse.
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While most of these studies in mammalian systems have been largely utilized the mouse, it is anticipated that transgenic approaches will only become more prevalent in other species such as the rat and pig.
Bound antibodies were detected utilizing the mouse EnVision+, HRP kit (Dako).
This result is similar to that reported by others utilizing the mouse [ 22].
The JNPL3 mouse model utilizes the mouse prion promoter [ 5] to drive mutant human tau expression [ 31].
To gain further physiological insight into furin function in mammalian placentation and pregnancy, we utilized the mouse model.
The PrP.SOD1-G37R SOD110ine 110 mice were generated by a vector that utilized the mouse prion protein promoter (MoPrP.Xho) containing a hSOD1 cDNA with the G37R mutation (20).
To evaluate the effects of IFN-γ on osteoclastogenesis, we utilized the mouse macrophage cell line RAW264.7 (RAW cells) or splenic macrophages from CBA/BL6 mice as osteoclast precursors.
In the present study, we utilized the mouse IL-18 combined with GM-CSF to modify the poorly immunogenic Lewis lung cancer LL/2 [ 25].
Currently, the vast majority of genetic models of human disease in mammals have utilized the mouse as an experimental animal [ 7].
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