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Glucose rates of appearance and utilization (trials 1 and 2) were calculated from 6,6 H2 glucose by using Steele's equations for non-steady state [ 25].
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A novel carbon utilization trial produced carbon dioxide treated concrete blocks by adding carbon dioxide gas to the concrete during the mixing and forming stages of the block production.
Resource utilization during trial and follow-up was derived from individual patient history data.
The in silico Spm analogues screening together with the availability of the recombinant SMO enzyme could be relevant to in vitro test analogues able to up-regulate SMO, before their utilization in clinical trials.
It also represents a new model for the utilization of clinical trials' bias-reduction principals in the analysis of retrospective data.
While the importance of developing better assessments cannot be overstated, their in-depth evaluation and eventual utilization in clinical trials is expected to take a significant amount of time.
The assessment of quantitative changes in liver fat in colocalized ROIs within each of the nine liver segments provides a robust framework for utilization in future trials in NASH.
Therefore, it is just as important for trial sponsors to include resource utilization measures in their trials as it is for decision makers to allow extrapolations beyond the clinical trial to best characterize and predict the full risk benefit profile of a new therapeutic agent.
Intervention costs were extrapolated based on observed resource utilization during the trial.
Yealy et al. [ 43] used graded-intensity level measures to improve guideline utilization in a trial-setting in US emergency departments.
Based on the health care utilization during the trial using the full Health Assessment Questionnaire, we will apply standard microcosting methods from the US Panel on Cost-effectiveness in Health and Medicine [ 68].
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