The coprimary efficacy objectives of this study are progression-free survival (PFS) and overall survival (OS); secondary objectives are overall response rate, changes in patient-reported pain and disease-related symptoms, changes in health status, resource utilization, safety and tolerability, and pharmacokinetics/pharmacodynamics.
Data derived from this source have been used for a variety of utilization, safety, and economic analyses (12– 12).
The founders of Uisee, which is an acronym for Utilization, Indiscriminate, Safety, Efficiency and Environment, say they believe the company will find a profitable niche between the poles of the driverless car debate that is raging in Silicon Valley.
Secondary outcomes include body weight, physical activity, medication use, cost, resource utilization, and safety.
The study will compare the oral LTRA montelukast with the inhaled LABA salmeterol, each administered on a background of inhaled fluticasone, on asthma attacks, quality of life, lung function, eosinophil levels, healthcare utilization, and safety, in approximately 1200 adult asthmatic patients.
These phases comprise: 1. Context, paradigms, philosophical understanding and utilization 2. Safety status 3. Comparative effectiveness.
The linked data have many applications in clinical epidemiology, including drug utilization studies, safety monitoring, etiologic research, and validation studies.
Almost 70% of patients with advanced prostate cancer have bone metastases. 1 Utilization and safety of novel therapies for metastatic cancer can be monitored using registry-based data.
Combining pharmacy records with laboratory data can generate important studies in clinical epidemiology, including drug utilization studies, safety monitoring, and etiologic research.
In addition, secondary objectives evaluated the impact of darbepoetin alfa EDS vs. QW administration on patient-reported outcomes, resource utilization, and safety parameters.
1– 7 Because pregnant women are typically excluded from randomized studies of drugs, evidence about drug utilization and safety in pregnant women comes primarily from surveillance.
