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The Diabetes Therapy Utilization: Researching Changes in A1C, Weight and Other Factors Through Intervention with Exenatide Once Weekly (DURATION-1) trial was designed as a two-stage protocol.
The six pivotal DURATION trials (The Diabetes Therapy Utilization: Researching Changes in A1c, Weight, and Other Factors Through Intervention With Exenatide Once Weekly) compare extended release exenatide to other antihyperglycemics.
In the Diabetes Therapy Utilization: Researching Changes in A1C, Weight and Other Factors Through Intervention with Exenatide Once Weekly (DURATION-1) study, the safety and efficacy of 30 weeks of treatment with the glucagon-like peptide-1 receptor agonist exenatide once weekly (exenatide QW; 2 mg) was compared with exenatide BID in 295 patients with type 2 diabetes.
As seen in the original DURATION (Diabetes Therapy Utilization: Researching Changes in A1C, Weight and Other Factors Through Intervention with Exenatide Once Weekly) -1 study, incidence of hypoglycemia was low and limited to patients who received exenatide in combination with a sulfonylurea.
This randomized trial (Diabetes Therapy Utilization: Researching Changes in A1C, Weight and Other Factors Through Intervention with Exenatide Once-Weekly [DURATION-4]) directly compared the safety and efficacy of EQW monotherapy versus MET, PIO, and SITA monotherapy in patients with type 2 diabetes who were suboptimally treated with diet and exercise but naive to antihyperglycemic drugs.
Six randomized controlled clinical trials, known by the acronym DURATION (Diabetes Therapy Utilization: Researching Changes in A1c, Weight and Other Factors Through Intervention with Exenatide Once Weekly), have been conducted on exenatide QW, each lasting 24 30 weeks [ 28– 33] (Table 1).
Similar(51)
The United States, for example, is spending $1 billion on carbon capture and utilization research.
To describe the use and reporting of interrupted time series methods in drug utilization research.
In this report, the utilization, research and development of corrosion inhibitors in Japan and the action mechanism of corrosion inhibitors are explained, and their effects and future utilization are also described.
Also, an international study found that the DDD system is a reliable tool for standardizing antipsychotic doses in drug utilization research [32].
Utilization research in medical sociology needs an explanatory model, keeping in view the complexities of the disorder itself i.e. psychosis and it's social complications [26].
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