Sentence examples for utilization of high dose from inspiring English sources
Although our data showed that α-tomatine inhibited the growth of normal prostate RWPE-1 cells at high concentration (5.0 µM), where utilization of high dose of α-tomatine can be a key consideration for cancer treatment, earlier in vivo studies showed no apparent toxic effects in rainbow trout [19] and does not affect body and liver weights of mice [14], [27].
Physical dependence may be produced after utilization of high doses for prolonged periods.
As a wide range of values have been reported for the concentrations of serum TMX following implantation of such pellets, as well as for TMX concentrations in the tumour, our central concern was to use a dosage that would not exceed tumour levels occurring during utilization of high-dose TMX for treatment of tumours in humans.
Moreover, the utilization of higher doses of meropenem administered as extended infusions further increased the probability of achieving bactericidal exposures for this resistant population of organisms.
Therapeutic administration of high doses of insulin results in an accumulation of myocardial glycogen stores and improvement in glucose utilization.
Utilization of a higher dose during initial therapy is also supported by other VTE trials that have shown that the highest risk of recurrent VTE occurs in the acute phase (initial 3 4 weeks) of treatment [ 54, 55].
Studies have shown increased lung utilization with high dose corticosteroids and hormonal therapy [ 6] while other research has shown minimal negative effects with use of corticosteroids in this group [ 7].
To demonstrate that utilization of the direction-modulated brachytherapy (DMBT) concept can significantly improve treatment plan quality in the setting of high-dose-rate (HDR) brachytherapy for cervical cancer.
Data were unavailable on over-the-counter purchases of high-dose aspirin and low-dose ibuprofen dosing schedules.
We considered other possible explanations for a steep increase such as the epidemic of obesity, increasing utilization of low-dose aspirin, and the higher utilization of high-fructose corn syrup or such dietary changes, but rejected them as the rate of increase was so obviously disproportionate to such long-term trends.
