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For this reason robust and reproducible analytical techniques are critical to ensuring proper validation and utilization of a biomarker.
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Supporting the utilization of CD64 as a biomarker of IFN-I levels, a concomitant reduction of CD64 expression on monocytes, but little effect on CD16 or CD32 expression was observed in all four patients (P < 0.006; paired t test; Figure 5b).
This limit of detection of CRP is acceptable to its utilization as a biomarker in diagnosis and in monitoring response to antibiotics [21].
This limit of detection of CRP is acceptable to its utilization as a biomarker in diagnosis and in monitoring response to antibiotics [ 21].
Age-independent expression of the MYOM3 fragments could be an advantage for utilization of this biomarker in gene therapy studies conducted in dogs.
Because of the HSM's utilization of a wide range of biomarkers spanning multiple organ systems, it may serve as a particularly effective clinical tool for early identification of at-risk individuals who may be asymptomatic at the time of measurement.
We clearly demonstrate the differences in the methylation profiles of basal-like and HER2-overexpressing tumors and provide evidence to support the utilization of this biomarker for prognostication and therapeutic stratification of patients with breast cancer.
Our results provide evidence that well-defined DNA methylation profiles enable breast cancer subtype prediction and support the utilization of this biomarker for prognostication and therapeutic stratification of patients with breast cancer.
The widespread utilization of this biomarker can be explained by the low cost of its assessment, the high sensitivity of existing CK assays, the excellent negative predictive value and also by a textbook explanation for the elevation of this protein in the blood of DMD patients: leakage due to the increased fragility of the sarcolemma in myofibres in the absence of dystrophin.
Several studies incorporating genetic susceptibility feedback testing have reported detailed information on uptake, but only a handful have commented on predictors of patient utilization of SNP-based biomarker testing for disease risk.
Gäddnäs and colleagues [ 1] report in a recent issue of Critical Care that the utilization of collagen metabolism biomarker levels retrospectively exhibited correlation with disease severity and differentiated between survivors and non-survivors in a cohort of patients with severe sepsis.
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