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Starch is mobilized providing glucose for further utilization in the glycolytic pathway and TCA cycle.
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We hypothesize that elevation of body temperature increases intracellular utilization of phosphate in the glycolytic pathway, causing phosphorus to shift from the extracellular fluid into cells.
An alternative mechanism is that the increase in lean muscle mass in the older mice will lead to greater carbohydrate utilization by the glycolytic muscle as opposed to its storage as fat in adipose tissue.
In fact, AMPK activation in the normal thyrocyte induces a dramatic reduction of iodide uptake that is accompanied by higher glucose uptake and utilization by the glycolytic pathway.
Overall, F-FDG uptake in malignancies reflects multifactorial mechanisms of increased metabolic activity and glucose utilization, performed by glucose transporters and enzymes in the glycolytic pathway, which in turn are regulated through different signaling pathways triggered by endogenous and exogenous stimulators.
Several enzymes involved in the glycolytic pathway were up-regulated by CHIKV or DENV-2 (Table S4), suggesting extensive glucose utilization during midgut infection.
Proteomics identified major changes in enzyme concentration in the glycolytic and tricarboxylic acid pathways.
We performed the same analysis with genes involved in the glycolytic pathway.
Indeed, myogenin has been previously shown to indirectly inhibit genes involved in the glycolytic pathway.
Enolase forms homodimers or heterodimers to convert 2-phosphoglycerate into phosphoenolpyruvate in the glycolytic pathway.
Also, no changes were predicted in the glycolytic pathway.
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