The prognostic utility of this score has only been demonstrated thus far in a single centre [ 14].
The original RFH score was subsequently validated in a cohort of patients with cirrhosis admitted to a general ICU and was found to perform better than both acute physiology and liver-specific scores, indicating the potential utility of this score in clinical practice (19).
Based on findings from our elderly cohort, inclusion of additional variables of history of pneumonia within 1 year of admission, history of MRSA infection, and high PSI score strengthen the utility of this new scoring system.
This example highlights the utility of the scoring scheme in providing information to identify tissue-specific associations between genes/proteins in molecular interaction networks and to rule out associations with low Xd-scores in a tissue of interest.
Besides, the ease of use, efficiency and general utility of the scoring functions should also be taken into account.
Thus, these results must be seen in the light of the purpose and utility of the scoring functions as described above.
The fact that the ratio scores were not significantly correlated is not surprising given that research has generally indicated a lack of clinical utility for this score [13, 14, 35].
The accompanying false discovery rates support the utility of these scores.
The performance and utility of these scores could be greatly improved by the integration of further preoperative and intraoperative variables.
