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Table 4 additionally shows permutation P values for six or more positive trends for each dose versus placebo without adjustment for multiplicity and they are 0.0022, 0.0021, 0.0017, and 0.0017 for the 10, 30, 100, 250 μg/kg/day doses, and their similarity supports the comparable utility of this criterion to identify departures from chance for the respective doses.
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Moreover, the low agreement between tests regarding OD kinetic tends to demonstrate the lack of utility of this potential criterion of cure.
In addition, given the lack of consensus concerning the utility of this diagnostic criteria in pregnancy [ 23– 25], we evaluated the extent to which snoring (i.e., those positive for section 1) is associated with maternal obesity status.
Since at present several diagnostic criteria of the metabolic syndrome (MS) exist, the objective of the study is to verify the utility of the criteria of the International Diabetes Federation (IDF) to diagnose the MS, their agreement with other previous definitions and the insulin resistance (IR).
A review of the limitations and utility of these criteria can be found in [ 66].
The utility of these criteria will be tested in future studies using prescribing datasets.
A validation study will be necessary to determine the utility of the criteria identified in practice.
Although it was possible to reduce the number of missing observations with supplemental (observed) data items, the prognostic utility of the criteria remained limited.
The PROMPT criteria may be applied to prescription-based datasets in the absence of clinical information to determine the prevalence of PIP, and the utility of these criteria will be tested in future studies using prescribing datasets.
The importance of a thorough evaluation for confounding illnesses is stressed by these results and further evaluation of the new criteria need to include disease controls to better reflect the utility of the criteria.
Although several diagnostic definitions have evolved over the years in an attempt to homogenise the heterogeneous ARDS population, the utility of these criteria outside clinical research remains controversial and their traction limited.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com