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The utility of these compounds showing hysteresis covers a broad area of applications, from the development of more efficient designs of temperature and pressure sensors to automotive and aeronautic industries and even a new type of molecular actuators.
The potency of a bis-trifluoromethyl analogue 74 and the unsaturated KGP18 derivative 73 as inhibitors of tubulin assembly along with their moderate cytotoxicity suggested the potential utility of these compounds as vascular disrupting agents (VDAs) to selectively target microvessels feeding tumors.
We have demonstrated the utility of these compounds by extracting different membrane proteins from prokaryote to higher eukaryote cell lines.
In this context, a variety of calpain inhibitors are under development and the potential clinical utility of these compounds have been shown mainly in the treatment of neurodegenerative disorders [10], [11], [12], [13].
No information on the utility of these compounds in animal models is yet available.
However, the clinical utility of these compounds still remains to be proven (Heinrich et al, 2010).
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The "volatile hypothesis" for lung cancer has led to a number of studies examining the utility of analyzing these compounds in exhaled breath using either animals (such as dogs) [13] or sophisticated biochemical techniques [14], [15].
Nevertheless, these results suggest the probable utility of combining these compounds with known sunscreens to maximize photoprotection.
As new antifungal agents are developed in response to the challenge of invasive fungal infections in immunocompromised patients with cancer, thoughtfully designed and carefully implemented clinical trials will be essential in determining the future utility of these promising compounds.
Therefore, this review catalogs recent advances in natural product-based drug discovery via the examination of mechanisms of action and available clinical data to highlight the utility of these novel compounds in the burgeoning age of precision medicine.
We now intend to study the synthetic utility of these new compounds and hope to make progress in PMDETA-solvated homometallic TMP chemistry with the results to be divulged in due course.
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supply of these compounds
relevance of these compounds
utility of these combinations
utility of these complex
utility of these product
utility of these connections
utility of these guidelines
utility of these estimators
utility of these tools
utility of these markers
utility of these cells
utility of these iCOGS
utility of these microdevices
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Justyna Jupowicz-Kozak
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